Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Depression Age: Adult |
Dose: by mouth – Initial: 50-75 mg/day; up to 150 mg/day if needed Note: Maximum: 300 mg/day in severe cases |
|
Indication: Neuropathic pain Age: Adult |
Dose: by mouth – Initial: 10-25 mg/day Frequency: at night Note: up to 75 mg/day if needed |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Depression Age: Adolescent |
Dose: by mouth (oral) – 25-50 mg/day Frequency: as a single dose (at bedtime) or in divided doses |
|
Indication: Nocturnal enuresis Age: 6-10 yr |
Dose: by mouth (oral) – 10-20 mg/day Frequency: at bedtime Duration: Maximum duration: 3 months |
Administration
- Take with food
- Take at bedtime
Side Effect
- Postural hypotension
- tachycardia
- conduction disturbances
- Dry mouth
- weight gain
- sour or metallic taste
- stomatitis
- constipation
- blurring of vision
- urinary retention
- fatigue
- dizziness
- weakness
- tremors
- headache
- confusion and delirium in elderly
- sexual disturbances
- peripheral neuropathy
- urticaria
- angioedema
- sweating
- Cardiac arrhythmias
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
SSRIs, TCAs, Triptans, Fentanyl, Lithium, Tramadol
|
Increased risk of serotonin syndrome
|
|
Barbiturates, Rifampicin, Other Anticonvulsants (Phenytoin, Carbamazepine, Valproic acid, Lamotrigine, Levetiracetam, Topiramate)
|
May reduce plasma levels
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Acute Recovery Phase Post-MI
|
Risk of heart complications
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.