Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Oedema Age: Adult |
Dose: Oral – Initially, 100 mg Frequency: daily Note: may adjust dose according to response up to 400 mg daily. |
|
Indication: Hepatic cirrhosis with ascites and oedema Age: Adult Condition: urinary Na/K ratio greater than 1 |
Dose: Oral – Initially, 100 mg Frequency: daily |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Hepatic cirrhosis with ascites and oedema Age: Child |
Dose: Oral – 3 mg/kg Frequency: in divided doses Note: initially, may adjust according to response |
|
Indication: Diagnosis of primary hyperaldosteronism Age: Child |
Dose: Oral – 3 mg/kg Frequency: in divided doses Note: initially, may adjust according to response |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment CrCl greater than 50 mL/min/1.73 m² |
Dose: 12.5-25 mg Frequency: once daily Note: use maintenance dose of 25 mg once daily or every 12 hours after 4 weeks of treatment with potassium less than 5 mEq/L |
|
Condition: Renal impairment CrCl 30-49 mL/min/1.73 m² |
Dose: 12.5 mg Frequency: once daily or every other day Note: use maintenance dose of 12.5-25 mg once daily after 4 weeks of treatment with potassium less than 5 mEq/L |
Administration
- Take with food
- Take at same time daily
Side Effect
- Drowsiness
- dizziness
- headache
- lethargy
- leg cramps
- GI disturbances (eg diarrhoea, cramps)
- ataxia
- mental confusion
- rashes
- pruritus
- alopecia
- hyponatraemia
- electrolyte disturbances
- gynaecomastia
- hirsutism
- menstrual irregularities
- breast pain
- deepening of the voice
- impotence
- leucopenia (including agranulocytosis)
- thrombocytopenia
- transient elevation in BUN concentration
- Rarely
- breast enlargement
- Hyperkalaemia
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Lithium
|
Increased risk of lithium toxicity
|
|
Potassium-sparing diuretics (Amiloride, Eplerenone, Spironolactone, Triamterene), K supplements, ACE Inhibitors (Captopril, Enalapril, Lisinopril, Ramipril, Benazepril, Fosinopril, Quinapril, Perindopril), Angiotensin II receptor antagonists, Trilostane, Heparin, LMWH
|
Increased risk of hyperkalaemia
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Anuria/Acute Renal Insufficiency
|
Can worsen kidney function
|
|
Hyperkalaemia
|
Can cause dangerous potassium levels
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool and dry place protected from light. Keep out of reach of children.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.