Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Acute Malaria Age: Adult |
Dose: Tablet – 5 tablets (Total 1250 mg) Frequency: single dose Note: If a full-treatment course does not lead to improvement within 48-72 hours, mefloquine should not be used for retreatment; an alternative therapy should be used. Similarly, if previous prophylaxis with mefloquine failed, mefloquine should not be used for curative treatment. |
|
Indication: Acute Malaria Age: Adult |
Dose: Tablet – 750 mg initial dose, followed by 500 mg Frequency: 6 to 12 hours after initial dose Note: Total dose 1,250 mg. If a full-treatment course does not lead to improvement within 48-72 hours, mefloquine should not be used for retreatment; an alternative therapy should be used. Similarly, if previous prophylaxis with mefloquine failed, mefloquine should not be used for curative treatment. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Acute Malaria Age: less than 6 months |
Dose: Oral – Safety and efficacy not established |
|
Indication: Acute Malaria Age: Pediatric (greater than 6 months) |
Dose: Oral – 20-25 mg/kg Frequency: once daily Note: given as single dose; Maximum total dose: 1250 mg |
Administration
- Take with food
- Take with full glass water
Side Effect
- Anxiety
- Difficulty concentrating
- Headache
- Insomnia
- Lightheadedness
- Vertigo
- Vomiting
- Diarrhea
- Stomach pain
- Nausea
- Visual disturbances
- Tinnitus
- Suicidal depression
- Psychiatric Sx
- Pneumonitis
- Seizure
- Abnormal ECG
- Seizures
- thrombocytopenia
- leucopenia
- AV block
- encephalopathy
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Quinine, Chloroquine, Antihistamines (Diphenhydramine, Loratadine, Levocetirizine, Cetirizine, Fexofenadine, Hydroxyzine, Bilastin), TCAs, Phenothiazines
|
Increased risk of ECG abnormalities
|
|
Quinidine, Quinine
|
May increase risk of seizure
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Hypersensitivity to quinine
|
Risk of severe reaction
|
|
Hypersensitivity to quinidine
|
Cross-sensitivity risk
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store in a cool dry place. Protect from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.