Medicine Overview
Adult Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Depression Age: Adult |
Dose: Oral – Initially, 20 mg Frequency: once daily Note: May gradually increase up to maximum 80 mg daily in 2 divided doses, if no clinical response after several weeks. |
|
Indication: Bulimia nervosa Age: Adult |
Dose: Oral – 60 mg Frequency: daily as a single or in divided doses Note: Hepatic impairment: Reduce dose and/or dosing frequency. |
Child Dose
| Clinical Information | Administration Information |
|---|---|
|
Indication: Depression Age: greater than 8 years |
Dose: Oral – 10 mg Frequency: once daily Note: may increase to 20 mg daily after 1-2 weeks |
|
Indication: Depression Age: greater than 8 years Condition: Low weight children |
Dose: Oral – 10 mg Frequency: once daily Note: may increase to 20 mg daily after several weeks, only if clinical response is insufficient |
Renal Dose
| Clinical Information | Administration Information |
|---|---|
|
Condition: Renal impairment |
Dose: Not specified Note: Use caution; drug accumulation may occur with severe renal impairment |
Administration
- Take with or without food
- Take in morning
Side Effect
- Headache (20-25%)
- Nausea (12-29%)
- Insomnia (10-33%)
- Anorexia (4-17%)
- Anxiety (6-15%)
- Asthenia (10-15%)
- Diarrhea (8-18%)
- Nervousness (8-14%)
- Somnolence (5-17%)
- Tremor (3-13%)
- Weakness (7-21%)
- Dizziness (9%)
- Dry mouth (6-10%)
- Dyspepsia (6-10%)
- Sweating (5-10%)
- Decreased libido (2-5%)
- Abnormal taste (More than 1%)
- Agitation (More than 1%)
- Chest pain (More than 1%)
- Chills (More than 1%)
- Confusion (More than 1%)
- Ear pain (More than 1%)
- Hypertension (More than 1%)
- Increased appetite (More than 1%)
- Palpitation (More than 1%)
- Sleep disorder (More than 1%)
- Tinnitus (More than 1%)
- Urinary frequency (More than 1%)
- Vomiting (More than 1%)
- Weight gain (More than 1%)
- Dysglycemia in patients with DM
- Risk of seizure with concomitant electroconvulsive therapy (rare)
- Rarely
- systemic events possibly related to vasculitis have been reported in patients with rash but may be serious involving lungs
- kidney and liver
Drug Interaction
Drug Interaction
| Drug Name | Risk Factors |
|---|---|
|
Warfarin, Digoxin
|
May cause transient shift in plasma concentration
|
|
Diazepam
|
T1/2 is prolonged
|
Disease Interaction
Disease Interaction
| Disease Name | Risk Factors |
|---|---|
|
Severe Renal Failure
|
Can worsen kidney function
|
|
Severe Hepatic Failure
|
Can worsen liver function
|
Pregnancy
Pregnancy
Lactation
Special Use
Precaution
Overdose
Pharmacology
Storage
Store between 20-25° C. Protect from light.
Data Sources
Clinical & regulatory information on this page is compiled from the following government sources:
DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Patients should always consult their physician with any questions regarding a medical condition and to obtain medical advice and treatment.